Histomorphological Study of the Anti-Fertility Effect of Spondias Mombin L. In Adult Male Rats
نویسندگان
چکیده
The effects of ethanol extract of Spondias mombin leaf on male rats’ fertility were investigated. The extract was orally administered with 250 and 500mg/kg doses for 8 weeks. There was significant decrease in testicular and epididymal weight in the treated animals compared to the control. Histomorphology of the testis showed distortion in the arrangement of seminiferous tubules, loose germinal epithelium, low number of germ cells and Sertoli cells. Tubular sizes of epididymis were reduced with vacuolation and decreased sperm. The serum level of testosterone was significantly decreased (p<0.05) at 500mg/kg compared to control. We conclude that Spondias mombin leaf extract can suppress the process of spermatogenesis which can lead to infertility in laboratory animals.
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